ProteinFind? Anti-CD166 Mouse Monoclonal Antibody
抗CD166鼠單克隆抗體
目錄號： HS906-01
單 價(jià)：￥660
產(chǎn)品詳情介紹
CD166又稱(chēng)為活化白細胞細胞粘附分子（ALCAM），是免疫球蛋白超家族的成員，在胞外區有五個(gè)免疫球蛋白樣結構域（VVC2C2C2）[1]。它在臍血造血干細胞、淋巴管內皮細胞、皮膚、扁桃體、外周血單核細胞、單核細胞衍生的樹(shù)突狀細胞上均有表達[2-5]。另外，CD166通過(guò)與T細胞表面糖蛋白CD6的相互作用促進(jìn)T細胞的活化與增殖[4,5]。本產(chǎn)品為小鼠抗人CD166單克隆抗體，用于FC方法特異性檢測人CD166蛋白。
CD系列產(chǎn)品介紹視頻
[1] Bowen MA, Patel DD, Li X, et al. Cloning, Mapping, and Characterization of Activated Leukocyte-Cell Adhesion Molecule (ALCAM), a CD6 Ligand [J]. J Exp Med. 1995, 181: 2213-20.
[2] Chitteti B R, Kobayashi M, Cheng Y, et al. CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche [J]. Blood. 2014, 124(4): 519-29.
[3] Iolyeva M, Karaman S, Willrodt AH, et al. Novel role for ALCAM in lymphatic network formation and function [J]. FASEB J. 2013, 27(3): 978-90.
[4] Hassan NJ, Barclay AN, Brown MH. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166 [J]. Eur J Immunol. 2004, 34(4): 930-40.
[5] Zimmerman AW, Joosten B, Torensma R, et al. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells [J]. Blood. 2006, 107(8): 3212-20.
