Recombinant Human GM-CSF Protein (GMP Grade)
GMP級重組人粒細胞- 巨噬細胞集落刺激因子蛋白
目錄號： PM115-01
單 價(jià)：￥880
產(chǎn)品詳情介紹
粒細胞-巨噬細胞集落刺激因子（Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF）是一種重要的細胞因子，它在免疫反應和炎癥過(guò)程中起著(zhù)關(guān)鍵作用。GM-CSF主要促進(jìn)粒細胞和巨噬細胞的增殖、分化和活化，同時(shí)調控T細胞的響應，對免疫系統的防御機制至關(guān)重要[1]。GM-CSF的表達受到精細的調控，這對于維持免疫平衡和防止自身免疫疾病的發(fā)展至關(guān)重要[2]。除了在免疫細胞中的重要作用，GM-CSF還可以通過(guò)激活p70 S6核糖體蛋白激酶信號通路來(lái)促進(jìn)中性粒細胞的趨化 [3]。GM-CSF的這些特性使其成為治療自身免疫疾病和炎癥性疾病的潛在靶點(diǎn)[4-5]。
[1] Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33.
[2] Gasson JC, Fraser JK, Nimer SD. Human granulocyte-macrophage colony-stimulating factor (GM-CSF): regulation of expression. Prog Clin Biol Res. 1990;338:27-41.
[3] Gomez-Cambronero J, Horn J, Paul CC, Baumann MA. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003 Dec 15;171(12):6846-55.
[4] Shiomi A, Usui T, Mimori T. GM-CSF as a therapeutic target in autoimmune diseases. Inflamm Regen. 2016 Jul 5;36:8. doi: 10.1186/s41232-016-0014-5.
[5] van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP. GM-CSF as a therapeutic target in inflammatory diseases. Mol Immunol. 2013 Dec;56(4):675-82.
